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Clinical Article Summaries

Clinical Article Summaries

Read our summaries of timely clinical research to help you stay current with information affecting your day-to-day practice.

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Effect of Antidepressant Switching vs Augmentation on Remission Among Patients With Major Depressive Disorder (MDD) Unresponsive to Antidepressant Treatment: the VAST-D Randomized Clinical Trial 

Clinical Article

Effect of Antidepressant Switching vs Augmentation on Remission Among Patients With Major Depressive Disorder (MDD) Unresponsive to Antidepressant Treatment: the VAST-D Randomized Clinical Trial 

Major depressive disorder (MDD) is a chronic condition that affects millions of Americans. Unfortunately, first-line monotherapy does not adequately address depressive symptoms for some MDD patients. The VA Augmentation and Switching Treatments for Improving Depression Outcomes (VAST-D) trial set out to determine the relative effectiveness and safety of 3 next-step treatments for MDD in patients who failed to respond adequately to at least 1 antidepressant treatment trial of adequate dose and duration. This clinical article summary shares the key findings of this landmark trial.

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Effect of Antidepressant Switching vs Augmentation on Remission Among Patients With Major Depressive Disorder (MDD) Unresponsive to Antidepressant Treatment: the VAST-D Randomized Clinical Trial 

Clinical article summary

Effect of Antidepressant Switching vs Augmentation on Remission Among Patients With Major Depressive Disorder (MDD) Unresponsive to Antidepressant Treatment: the VAST-D Randomized Clinical Trial 

Major depressive disorder (MDD) is a chronic condition that affects millions of Americans. Unfortunately, first-line monotherapy does not adequately address depressive symptoms for some MDD patients. The VA Augmentation and Switching Treatments for Improving Depression Outcomes (VAST-D) trial set out to determine the relative effectiveness and safety of 3 next-step treatments for MDD in patients who failed to respond adequately to at least 1 antidepressant treatment trial of adequate dose and duration. This clinical article summary shares the key findings of this landmark trial.
Combining Medications to Enhance Depression Outcomes (CO-MED): Acute and Long-term Outcomes of a Single-blind Randomized Study

Clinical article summary

Combining Medications to Enhance Depression Outcomes (CO-MED): Acute and Long-term Outcomes of a Single-blind Randomized Study

Major depressive disorder (MDD) is a chronic and disabling condition that affects up to 12% of men and 25% of women. MDD is recurrent, with many patients not achieving complete recovery between depressive episodes. The aim of treatment for MDD is remission, which is associated with improved functioning and prognosis.
Cross-cultural Adaptation of the Arabic Positive and Negative Syndrome Scale in Schizophrenia: Qualitative Analysis of a Focus Group

Clinical article summary

Cross-cultural Adaptation of the Arabic Positive and Negative Syndrome Scale in Schizophrenia: Qualitative Analysis of a Focus Group

Studies looking at the diagnosis of schizophrenia are often completed in Western countries. Here, we review the process and importance not only of translation but also of cultural adaptation of a psychiatric rating scale, concentrating on the Positive and Negative Syndrome Scale (PANSS) in patients of Arab descent with schizophrenia. The authors explore issues related to interview structure and cultural sensitivity within varied populations.
Acute and Longer-Term Outcomes in Depressed Outpatients Requiring One or Several Treatment Steps: A STAR*D Report

Clinical article summary

Acute and Longer-Term Outcomes in Depressed Outpatients Requiring One or Several Treatment Steps: A STAR*D Report

The Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial was a 7-year nationwide clinical trial designed to evaluate the efficacy of different medications in patients who did not respond to an initial antidepressant. Rush et al. (2006) evaluated acute and long-term treatment outcomes in patients who participated in the STAR*D trial and identified differences in response and remission rates and time to remission across patients who received up to four sequential treatment steps.
The Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) Study and Its Implications for Patients With Chronic Schizophrenia

Clinical article summary

The Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) Study and Its Implications for Patients With Chronic Schizophrenia

Lieberman et al reported efficacy and tolerability results from the first phase of the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) study, which compared first- generation antipsychotic medication with second-generation antipsychotic medication in people with schizophrenia. McEvoy et al and Stroup et al then reported efficacy and tolerability results from the second phase of CATIE, which compared responses to subsequent therapy with a different second-generation antipsychotic in people with schizophrenia who discontinued their previous second-generation antipsychotic.
The Rapid Mood Screener (RMS): A Novel and Pragmatic Screener for Bipolar I Disorder

Clinical article summary

The Rapid Mood Screener (RMS): A Novel and Pragmatic Screener for Bipolar I Disorder

McIntyre et al developed a simple 6-question Rapid Mood Screener (RMS) to screen for manic symptoms and features of bipolar I disorder.
Clinician Descriptions of Communication Strategies to Improve Treatment Engagement by Racial/Ethnic Minorities in Mental Health Services: A Systematic Review

Clinical article summary

Clinician Descriptions of Communication Strategies to Improve Treatment Engagement by Racial/Ethnic Minorities in Mental Health Services: A Systematic Review

Aggarwal et al (2016) conducted a systematic literature review to identify patient-clinician communication factors that could account for low mental health treatment engagement rates among patients of racial/ethnic minority status.
Adjunctive Antidepressant Use and Symptomatic Recovery Among Bipolar Depressed Patients With Concomitant Manic Symptoms: Findings From the STEP-BD Study

Clinical article summary

Adjunctive Antidepressant Use and Symptomatic Recovery Among Bipolar Depressed Patients With Concomitant Manic Symptoms: Findings From the STEP-BD Study

Goldberg et al evaluated patients from the naturalistic treatment assignment of the STEP-BD study to determine whether antidepressant medications are effective in treating patients with bipolar depression with subsyndromal manic features.

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